Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:52 PM
Ignite Modification Date:
2025-12-24 @ 7:52 PM
NCT ID:
NCT03803904
Eligibility Criteria:
Inclusion Criteria:
* Adults aged 65-80 who do not regularly exercise
* defined as exercising less than 20 minutes twice per week
* Are willing and able to cooperate with assessments and interventions
* Participant will be quantified at or below the "poor" range for cardiovascular fitness as assessed by a volume of oxygen (VO2) test
* 26.0 ml/kg/min for males
* 21.0 ml/kg/min for females)
* 26 on the MoCA to meet the criteria for cognitively intact
* Participants will be free from diseases affecting cognition or that would interfere with their ability to engage in aerobic exercise - including but not limited to:
* chronic heart
* liver
* kidney disease
* Free from diseases/injuries directly affecting brain functions - including but not limited to:
* significant closed head injury
* open intracranial wounds
* stroke
* epilepsy
* degenerative diseases of the nervous system
* All subjects will speak English as a primary language and will have at minimum a high school diploma so that behavioral/cognitive measures reflect effects of aging and aerobic exercise and not unfamiliarity with the English language or a lack of education
Exclusion Criteria:
* Potential participants with major psychiatric disorder - including but not limited to:
* psychosis
* major depression
* bipolar disorder
* Individuals with ongoing drug or alcohol abuse and severe hypertension (systolic BP \> 200 or diastolic BP \> 110 mm Hg or subjects taking three or more antihypertensive medications
* Participants must not have conditions incompatible with MRI - including but not limited to:
* ferrous metal implants
* cardiac pacemakers or similar devices
* claustrophobia
* morbid obesity
* Persons engaging in significant skilled manual movements regularly will be excluded so that behavioral/motor measures reflect the effects of age and aerobic exercise and not the effects of frequent practice
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
65 Years
Maximum Age:
80 Years
Study:
NCT03803904
Study Brief:
Protocol Section:
NCT03803904