Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:37 PM
Ignite Modification Date:
2025-12-24 @ 7:37 PM
NCT ID:
NCT06215703
Eligibility Criteria:
Inclusion Criteria:
For participants with stroke, to be eligible to participate in this study, an individual must meet all the following criteria:
* hemiparesis resulting from a stroke (ischemic or hemorrhagic) at least 6 months before the enrollment into the study
* age from 18 to 89 years
* ability to move the wrist flexor and extensor muscles without help from the healthy side, scoring above 3 on the Medical Research Council (MRC) Scale for Muscle Strength, reflecting active movement against gravity
* no more than mild resistance to passive movement in the wrist extensor muscle - as demonstrated by a score \<2 on the Ashworth Scale (Brashear et al.., 2002)
* a modified Rankin Scale (mRS) \< 3 indicating moderate to mild disability and the ability to ambulate independently (Bonita \& Beaglehole, 1988)
* ability to comprehend language and provide informed consent
* consenting to participate and willingness to complete MRI testing procedures
For neurologically normal control (NC) participants, to be eligible to participate in this study, an individual must meet all the following criteria:
* be matched for age, gender, and socioeconomic status (education level) to a previously enrolled participant with stroke
* age from 18 to 89 years
* no history of neurological injury
* ability to comprehend language and provide informed consent
* consenting to participate and willingness to complete MRI testing procedures
Exclusion Criteria:
* history of neurological injury other than stroke
* moderate to severe depression symptoms indicated by a score \>10 on the Patient Health Questionnaire - 9 (PHQ-9; Koenke et al., 2001; Williams et al., 2005)
* visual impairment unable to be corrected with glasses/contact lenses sufficient to allow reading comprehension
* actively performing or practicing a musical instrument more than 2 hours/week
* musical anhedonia indicated by a score \< 65 on the Barcelona Music Reward Questionnaire (BMRQ; Mas-Herrero et al., 2013)
* amusia as measured by the Montreal Battery of the Evaluation of Amusia (MBEA; Peretz et al., 2003)
* not being compatible with MRI testing, including having implanted devices, previous exposure to metallic fragments, large tattoos, claustrophobia, and pregnancy
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
89 Years
Study:
NCT06215703
Study Brief:
Protocol Section:
NCT06215703