Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:36 PM
Ignite Modification Date:
2025-12-24 @ 7:36 PM
NCT ID:
NCT03516903
Eligibility Criteria:
Inclusion Criteria:
* Patients with type 1 STEMI, documented by: ischemic symptoms, new ST-elevation at the J-point in two contiguous leads (0.2 mV in men or 0.15 mV in women in leads V2-V3 and/or 0.1 mV in other leads or new left bundle branch block \[LBBB\]) and cardiac biomarkers (troponin and/or creatine kinase MB) with at least one value above the 99th percentile of the upper reference limit (URL).
* Submitted to any successful repercussion strategy (thrombolysis or angioplasty).
* Coronary angiography showing successful reperfusion therapy (Thrombolysis in Myocardial Infarction \[TIMI\] flow grade 3 in the infarct-related artery) and residual obstruction in the infarct-related artery \< 50%.
* Asymptomatic, without signs of clinical decompensation (heart rate \< 100bpm, systolic blood pressure \> 90mmHg, without vasoactive dor inotropic drugs, pulse oximetry \> 95% with FiO2 21%).
* Signing the study informed consent.
Exclusion Criteria:
* History of AMI.
* Estimated glomerular filtration rate \< 40 mL/min/1.73 m2.
* Contraindications for CMR: pacemaker, metallic devices, claustrophobia, obesity over 150 kg total weight.
* Prior history of chronic infectious disease, including tuberculosis, severe fungal disease, or known HIV positive.
* Chronic hepatitis B or C infection.
* Interstitial pneumonitis, bronchiectasis, or pulmonary fibrosis.
* Chest x-ray evidence in the past 12 months of interstitial pneumonitis, bronchiectasis, or pulmonary fibrosis.
* Prior history of nonbasal cell malignancy or myeloproliferative or lymphoproliferative disease within the past 5 years.
* White blood cell count \<4000/mm3, hematocrit \<32%, or platelet count \<75000/mm3.
* Alanine aminotransferase levels (ALT) greater than 2-fold the upper limit of normal.
* History of alcohol abuse or unwillingness to limit alcohol consumption to \< 4 drinks per week.
* Pregnancy or breastfeeding.
* Women of child bearing potential, even if currently using contraception.
* Men who plan to father children during the study period or who are unwilling to use contraception.
* Requirement for use of drugs that alter folate metabolism (trimethoprim/sulfamethoxazol) or reduce tubular excretion (probenecid) or known allergies to antibiotics making avoidance of trimethoprim impossible.
* Current indication for methotrexate therapy.
* Chronic use of oral steroid therapy or other immunosuppressive or biologic response modifiers.
* Known chronic pericardial effusion, pleural effusion, or ascites.
* New York Heart Association class III-IV congestive heart failure.
* Life expectancy of \< 1 years.
* Active infection.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
75 Years
Study:
NCT03516903
Study Brief:
Protocol Section:
NCT03516903