Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:36 PM
Ignite Modification Date:
2025-12-24 @ 7:36 PM
NCT ID:
NCT01072903
Eligibility Criteria:
Inclusion Criteria:
* Any sex, race, or ethnicity.
* At least 18 years of age (no upper age limit).
* D-IBS and M-IBS patients must meet Rome II criteria for IBS and must have been evaluated by a physician to exclude alternative diseases that could explain the symptoms. For the latter, patients' self statement is acceptable (by self-report, no official document is required).
* D-IBS and M-IBS subjects older than 50 years old must have had a colonoscopy in the past 5 years with a normal report. Hemorrhoids, diverticulosis and polyps are allowed.
* Participation in Dr. Whitehead's heterogeneity of IBS research study, or Dr. Ringel's Probiotic Pain Study.
Exclusion Criteria:
* Healthy controls must have no significant or recurring gastrointestinal symptoms.
* Patients and healthy controls should not have a serious, unstable medical condition.
* Patients and healthy controls must have had no gastrointestinal tract surgery other than appendectomy or cholecystectomy, or any abdominal surgery within the past 3 months. Appendectomy and cholecystectomy are allowed if done more than 2 years ago and symptoms were not changed following the surgery.
* Pregnancy and breastfeeding (by self-report).
* No history of inflammatory bowel diseases, celiac disease, or other diagnosis that could explain chronic or recurring bowel symptoms in IBS patients or controls (by self-report).
* Patients and controls should have no history of lactose malabsorption (by self-report).
* Patients and controls should have no history of clinical symptoms of acute infections during the last 8 weeks prior to enrollment in the study.
* Patients and controls should have no history of anti-inflammatory agents including aspirin, non-aspirin, non-steroid anti-inflammatory (NSAID), steroids, antibiotic, or probiotics treatment during the last 4 weeks prior to enrollment in the study.
* Patients should not have an implanted or portable electro-mechanical medical device such as a pacemaker and/or other implanted stimulators or pumps.
* Evidence of acute inflammation on routine histology.
* Evidence of enteric pathogens on routine stool cultures.
* Presence of a medical condition that requires routine use of antibiotic treatment with dental or other invasive procedures (by self-report).
* To be confirmed at time of screening and the week of the flexible sigmoidoscopy appointment for IBS-M subjects ONLY: In the past week, subject cannot have less than 3 (0-2) bowel movements. Also, in the past week, subject cannot have hard/lumpy stools for 2 or more days.
Only subjects with IBS may participate in the optional SmartPill testing. Subjects are excluded from SmartPill testing if a subject has:
* A history of gastric bezoar.
* Suspected strictures, fistulas, colon cancer or other physiological GI obstruction.
* Dysphagia.
* Diverticulitis.
* Tobacco use within eight hours prior to capsule ingestion and during the initial 8 hour recording on Day 0 or the Ingestion visit.
* Alcohol use within eight hours prior to capsule ingestion and throughout the entire monitoring period (5 days).
* Body Mass Index \> 40 kg/m2.
* Female of childbearing age who is not practicing birth control and/or are pregnant or lactating.
* Cardiovascular, endocrine, renal, or other chronic disease likely to affect motility.
* A medical device such as a pacemaker, infusion pump, or insulin pump.
* Any contraindication to use of Fleets Enema or the balloon expulsion test.
* Uncontrolled diabetes with a hemoglobin A1C greater than 10.
* Allergies to any of the ingredients of the standard SmartBar meal
* Subject plans to take any of the following prohibited medications: Medication to alter gastric pH, Medication that affect GI motility for 3 full days before the start of the study and during the ensuing days of study, Medication for nausea and vomiting that block serotonin receptors, Anti-diarrheal agents, Opiate agents used to treat diarrhea, Non-steroidal anti-inflammatory drugs
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT01072903
Study Brief:
Protocol Section:
NCT01072903