Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:18 PM
Ignite Modification Date:
2025-12-24 @ 7:18 PM
NCT ID:
NCT04277403
Eligibility Criteria:
Inclusion Criteria:
* At least 4 and not exceeding 15 brain metastases not exceeding a combined total volume of 25ml and not previously treated with radiotherapy
* KPI ≥ 70, ECOG ≤ 2
* Age ≥ 18 years, Male or female
Exclusion Criteria:
* Neuroendocrine, SCLC, germinoma or lymphoma histology
* Brain stem metastasis
* Life expectancy \< 3 months
* Suspicion of meningeosis carcinomatosa
* Previous WBRT
* Inability to participate in radiologic follow-up, contraindication to MR imaging (e.g. not MRI compatible pacemaker, severe claustrophobia)
* Inability to participate in neurocognitive function testing, insufficient German language skills, aphasia, graphomotor impairment, insufficient vision, insufficient attention span
* Pregnancy, nursing or unwillingness to prevent pregnancy using effective methods of contraception during treatment
* Known abuse of medication, drugs or alcohol
* Known severe dementia (z-score \< 2) or major cognitive function disorder that is not caused by intracranial tumour
* Known clinical depression or psychotic disorder
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT04277403
Study Brief:
Protocol Section:
NCT04277403