Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:10 PM
Ignite Modification Date:
2025-12-24 @ 7:10 PM
NCT ID:
NCT01108003
Eligibility Criteria:
Inclusion Criteria:
* Any patient eligible for superficial bladder cancer
* Patients must be considered fit for surgical resection with curative intent
* No chemotherapy, surgery (excluding transurethral resection of bladder tumor \[TURBT\], BCG or radiotherapy in the prior 4 weeks \[6 weeks for mitomycin C or interferon\])
* No previous treatment/ingestion with broccoli extracts
* Eastern Oncology Group (ECOG) performance status 0-2
* AST and ALT =\< 2.5 times ULN (upper limit of normal)
* Total bilirubin =\< 2.0 mg/dL
* Creatinine Clearance \>= 30 ml/min
* WBC \> 3000 mm\^3
* Absolute neutrophil count \> 1000/mm\^3
* Platelets \> 100,000/mm\^3
* All patients must sign a study-specific consent form indicating that they are aware of the investigational nature of this study
Exclusion Criteria:
* Have participated in any clinical trial involving conventional or investigational drugs or devices within the previous 4 weeks
* Prior radiation to the pelvis
* Intractable urinary tract infection that has not responded to antibiotic treatment
* Active, uncontrolled bacterial, viral, or fungal infection including HIV
* Have had major surgery within 4 weeks of starting therapy (not including placement of vascular access device or TURBT)
* Poor medical risk in the opinion of the treating oncologist due to non-malignant systemic disease
* Pregnant or lactating patients: patients must be postmenopausal or practicing an accepted form of birth control; for patients where pregnancy is a possibility, a pregnancy test will be required prior to initiation of therapy
* Have a history of myocardial infarction or angina pectoris/angina equivalent in the last 6 months (the patient may be on anti-anginal medications if the symptoms have been entirely controlled for greater than 6 months), or have uncontrolled congestive heart failure
* Have a history of bleeding disorders or thrombosis; patients on therapeutic doses of anticoagulation (including coumadin or heparins) are not permitted on trial (this exclusion criterion does not include those patients receiving low dose or prophylactic dose anticoagulation \[i.e. coumadin 1 mg daily in patients with central intravenous lines\])
* Radiotherapy during the course of the trial
* Inability to tolerate proposed treatment or procedures
* Have additional uncontrolled serious medical conditions or psychiatric illness
* Patients with a history of hepatitis (including but not exclusive to viral hepatitis auto-immune or alcoholic)
* Patients with active thyroid disease (patients with hypothyroidism, adequately replaced on a stable dose of thyroid replacement will be allowed on trial)
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT01108003
Study Brief:
Protocol Section:
NCT01108003