Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:10 PM
Ignite Modification Date:
2025-12-24 @ 7:10 PM
NCT ID:
NCT02501603
Eligibility Criteria:
Inclusion Criteria:
1. Histologically or cytologically confirmed locally advanced or metastatic gastric cancer and gastroesophageal junction cancer
2. EGFR 2+ or 3+ expression (immunohistochemistry)
3. ECOG performance status of 0 to 1
4. Male or female; ≥ 19 years of age
5. Documented disease progression after one prior therapy, in locally advanced or metastatic setting
6. patients received last adjuvant chemotherapy less than six months can be enrolled into this study
7. Her2 positive patients must be progressed after prior trastuzumab based chemotherapy
8. Subjects with measurable lesion (using RECIST 1.1 criteria)
9. Subjects who meet the following criteria:
* Absolute neutrophil count (ANC) ≥ 1000 /µL (\*ANC = Neutrophil segs ＋ Neutrophil bands)
* Platelet count ≥ 80,000/ µL
* Serum creatinine \< 1.5 x upper limit of normal (ULN) or Creatinine clearance ≥50 mL/min using Cockcroft, Gault method
* AST (SGOT) and ALT (SGPT) : 3 x upper limit of normal (ULN) (If there is Liver Metastasis : 5 x upper limit of normal (ULN))
* Total bilirubin : 1.5 x upper limit of normal (ULN)
10. Provision of written informed consent prior to any study procedure
Exclusion Criteria:
1. Any unresolved chronic toxicity greater than CTC grade 2 from previous anticancer therapy.
2. Any previous chemotherapy or immunotherapy within 2 weeks
3. Any major operation or irradiation within 4 weeks of baseline disease assessment
4. Two or more previous systemic cytotoxic chemotherapy (adjuvant chemotherapy is not counted)
5. Any clinically significant gastrointestinal abnormalities which may impair intake or absorption of the study drug
6. Previously taxol(paclitaxel)-exposed patients
7. Subjects with symptomatic central nervous system (CNS) metastases who are neurologically unstable or have required increasing doses of steroids within the 2 weeks prior to study entry to manage CNS symptoms
8. Other co-existing malignancies or malignancies diagnosed within the last 3 years with the exception of basal cell carcinoma, thyroid cancer or cervical cancer in situ.
9. Subjects with an uncontrolled major cardiovascular disease (including AMI within 12 months, unstable angina within 6 months, over NYHA class III congestive heart failure, congenital long QT syndrome, 2° or more AV Block and uncontrolled hypertension)
10. Pregnant or lactating female
11. Patients with contraindicated medication
12. History of interstitial lung disease (ILD) or presence of ILD on chest X-ray
13. Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
19 Years
Study:
NCT02501603
Study Brief:
Protocol Section:
NCT02501603