Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:10 PM
Ignite Modification Date:
2025-12-24 @ 7:10 PM
NCT ID:
NCT02961803
Eligibility Criteria:
Inclusion Criteria:
* ABCD1 gene mutation identified
* Elevated plasma VLCFA
* Clinical signs of AMN with at least pyramidal signs in the lower limbs and difficulties to walk
* EDSS score ≥ 3.5 and ≤ 6.5
* Normal brain MRI or brain MRI showing :
* abnormalities that can be observed in AMN patients without cerebral demyelination with a maximum Loes score of 4
* and/or stable (≥6 months) cerebral demyelination without gadolinium enhancement with a Loes score ≤12.
* Appropriate steroid replacement if adrenal insufficiency is present
* Likely to be able to participate in all scheduled evaluation visits and complete all required study procedures
* Signed and dated written informed consent to participate in the study in accordance with local regulations
* Affiliated to a Health Insurance
Exclusion Criteria:
* Brain MRI abnormalities with a Loes score \> 12 or with gadolinium enhancement
* Any progressive neurological disease other than AMN
* Impossibility to perform the walk tests and the TUG test
* Patients with uncontrolled hepatic disorder, renal or cardiovascular disease, or any progressive malignancy
* Any new medication for AMN including Fampridine initiated less than 1 month prior to inclusion
* Contra-indications for MRI procedure such as subjects with paramagnetic materials in the body, such as aneurysm clips, pacemakers, intraocular metal or cochlear implants.
* Inclusion in another therapeutic clinical trial for ALD
* Not easily contactable by the investigator in case of emergency or not capable to call the investigator
Healthy Volunteers:
False
Sex:
MALE
Minimum Age:
18 Years
Maximum Age:
60 Years
Study:
NCT02961803
Study Brief:
Protocol Section:
NCT02961803