Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:06 PM
Ignite Modification Date:
2025-12-24 @ 7:06 PM
NCT ID:
NCT03574857
Eligibility Criteria:
Inclusion Criteria:
* Age \> 18 years old
* Admitted for acute decompensated HF with left ventricular ejection fraction (LVEF) \<40%
* Refractory fluid overload:
* Unresponsive (\<500 mL net negative over previous 24 hours) AND ineffective diuresis (determined by HF team) to moderate intensity push or low intensity continuous infusion loop diuretic (80 mg IV furosemide or equivalent bumetanide dose of 4 mg)
* English or Spanish-speaking subjects
* Willing and able to comply with study procedures
Exclusion Criteria:
* Baseline thiazide use prior to admission or prior to study enrollment
* Renal replacement therapies (RRT) or glomerular filtration rate (GFR) \<30 mL/min at the time of enrollment
* Pregnant women
* Cognitive impairment
* Prisoners
* Left ventricular assist devices (LVAD) or temporary mechanical circulatory support devices
* History of cardiac transplant
* Reported allergy to thiazides
* No enteral access or unable to take medications enterally
* Palliative diuretics
* Systolic blood pressure (SBP) \<90 mm Hg prior to randomization
* Patients receiving concomitant lithium therapy
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT03574857
Study Brief:
Protocol Section:
NCT03574857