Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:02 PM
Ignite Modification Date:
2025-12-24 @ 7:02 PM
NCT ID:
NCT05611957
Eligibility Criteria:
Inclusion Criteria:
Normal Participants:
* Healthy male and female participants as determined by physical examination
* Participants with normal renal function assessed by estimated glomerular filtration rate (eGFR) ≥ 90 milliliter per minute (mL/min).
* Body mass index (BMI) ≥ 19.0 and ≤ 40.0 kilograms per meter squared (kg/m²)
* Male participants who agree to use contraception and female participants of child bearing potential must agree to use contraceptive methods and women not of child bearing potential can participate.
Participants with Renal Impairment:
* Have acceptable blood pressure (BP) and pulse rate, as determined by the investigator
* Participants with type 2 diabetes must have a glycated hemoglobin (HbA1c) ≥ 5.0% and ≤ 11.5%
* Are males or females with severe renal impairment as determined by a stable eGFR \<30 mL/min, not requiring hemodialysis OR
* Are males or females with end-stage renal disease (have received hemodialysis for at least 3 months)
Exclusion Criteria:
* Have known allergies to LY3437943 or related compounds
* Have a current, functioning organ transplant. Nonfunctional renal allografts may be allowed
* Have any abnormality in the 12-lead electrocardiogram (ECG)
* Are women with a positive pregnancy test or women who are lactating
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
85 Years
Study:
NCT05611957
Study Brief:
Protocol Section:
NCT05611957