Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 6:28 PM
Ignite Modification Date:
2025-12-24 @ 6:28 PM
NCT ID:
NCT04334668
Eligibility Criteria:
Inclusion Criteria:
* Age ≥ 18 years old AND
* Admitted to cardiology floor (non-ICU) with primary diagnosis of decompensated heart failure AND
* NT-proBNP \>1000 ng/L AND
* Initiation of continuous furosemide infusion at a rate of 10 mg/hr or higher
Exclusion Criteria:
* Serum sodium (Na+) level less than 120 or greater than 145.
* Average Systolic Blood Pressure \>180 mmHg or Diastolic Blood Pressure \>100 mmHg over past 24 hours.
* Anticipated length of stay less than 72 hours.
* Use of vasopressin antagonist
* Current use of sodium chloride tablets
* Active diagnosis of diabetes insipidus
* Inability to tolerate oral diet or swallow pills
* Presence of malabsorptive gastrointestinal disorder (Crohn's disease, short gut syndrome)
* The use of iodinated radiocontrast material in the past 72 hours or anticipated use of intravenous contrast during the current hospitalization
* Admission with intention to transplant or implant permanent Ventricular Assistive Device
* Use of intravenous inotropes, vasopressors or vasodilators at enrollment
* A baseline estimated glomerular filtration rate \<15 mL/min/1.73m² according to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula at the moment of inclusion
* Use of renal replacement therapy at time of enrollment
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT04334668
Study Brief:
Protocol Section:
NCT04334668