Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 5:55 PM
Ignite Modification Date:
2025-12-24 @ 5:55 PM
NCT ID:
NCT05348668
Eligibility Criteria:
Inclusion Criteria:
* 18-75 years old;
* Eastern Cooperative Oncology Group (ECOG) 0-1;
* Non-small cell lung cancer, including squamous-cell carcinoma, adenocarcinoma, large-cell carcinoma, adenosquamous carcinoma;
* Stage IVA and IVB confirmed by radiological examination (AJCC 8th Edition);
* Driven-genes negative including EGFR (Epidermal Growth Factor Receptor), ALK (Anaplastic Lymphoma Kinase), ROS1 (ROS Proto-Oncogene 1), KRAS G12C (Kirsten Rat Sarcoma Viral Oncogene), BRAF V600E (v-raf murine sarcoma viral oncogene homolog B1), MET exon14 (Mesenchymal Epithelial Transition Factor), RET (Rearranged during Transfection Proto-oncogene), NTRK1/2/3 (NeuroTrophin Receptor Kinase);
* First-line treatment of ICI±chemotherapy;
* Partial response (PR) or stable (SD) after first-line treatment;
* Signature of inform consent.
Exclusion Criteria:
* younger than 18 years old or older than 75 years old;
* ECOG\>1;
* Small-cell lung cancer and other neuroendocrine carcinoma;
* Non stage IV confirmed by radiological examination;
* Driven-genes positive including EGFR, ALK, ROS1, KRAS G12C, BRAF V600E, MET exon14, RET, NTRK1/2/3;
* First-line treatment of other therapy rather than ICI±chemotherapy;
* Complete response (CR) or progression (PD) after first-line treatment;
* Contraindications for radiotherapy, chemotherapy and ICI;
* No signature of inform consent.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
75 Years
Study:
NCT05348668
Study Brief:
Protocol Section:
NCT05348668