Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 5:39 PM
Ignite Modification Date:
2025-12-24 @ 5:39 PM
NCT ID:
NCT01316068
Eligibility Criteria:
Inclusion Criteria:
* Diagnosis of type 2 diabetes based on WHO criteria
* Age 18-75 years old
* Serum creatinine ≤ 1.5 mg/dL (130umol/L)
* Albuminuria defined by a urine albumin/creatinine ratio(ACR) according to ADA criteria 2009 (microalbuminuria by 30-299 ug albumin/mg creatinine and macroalbuminuria by ≥300 ug albumin/mg creatinine on random spot urine collection )
* Continued stable seated systolic blood pressure \< 180 mmHg and diastolic blood pressure \< 110 mmHg
* Willing to change antihypertensive medication regimen if necessary
* Willing to provide written informed consent to participate in the study
* Willing to take contraception,or infertility for the duration of the study
Exclusion Criteria:
* Type 1 diabetes mellitus
* Present acute diabetic complication, or severe chronic diabetic complication(e.g. proliferative diabetic retinopathy)
* Complicating uncontrolled severe infection
* Hepatic insufficiency or renal insufficiency or severe disturbance of lipid metabolism
* Blood pressure ≥ 180/110mmHg
* Severe concomitant systemic disease(e.g. cardiac insufficiency, stroke), anticipated to be unable to finish the trial
* Uncooperative,unable to follow up, or anticipated unable to finish the trial
* Patients with other known specific renal diseases
* Untreated urinary tract infection that would impact urinary protein values
* Evidence of hepatic dysfunction including total bilirubin \> 2.0 mg/dL (34 mmol/L) or elevated transaminases
* History of Cardiovascular disease as follows: Unstable angina pectoris, myocardial infarction, transient ischemic attack, cerebrovascular accident, New York Heart Association Functional Class III or IV heart failure, obstructive valvular heart disease or hypertrophic cardiomyopathy
* Any risk of bleeding, or platelet count \< 100×109/L or anticipated surgery within research period
* Active, recurrent or metastatic cancer, or known HIV infection
* Participant in any experimental drug study in the past 90 days prior to the enrollment of the study, or plan to participate in any drug study during the study period
* Prior exposure to sulodexide, either in a clinical setting or as a participant in another clinical study
* Known allergy or intolerance to any heparin-like compounds or multiple drug allergies
* Lactation, pregnancy, or an anticipated or planned pregnancy during the study period
* Inability to give an informed consent or to cooperate with researchers (e.g. psychiatric disorder) or history of noncompliance to medical regimen
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
75 Years
Study:
NCT01316068
Study Brief:
Protocol Section:
NCT01316068