Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 5:25 PM
Ignite Modification Date:
2025-12-24 @ 5:25 PM
NCT ID:
NCT04339868
Eligibility Criteria:
Inclusion Criteria:
* Septic shock according to Sepsis-3 definition
* Evidence of adequate fluid
* Received norepinephrine 0.2 mcg/kg/min or more
* Received norepinephrine plus epinephrine (any dose)
* Mean arterial lower than 65 mmHg or lactate \> 2 mmol/liter
Exclusion Criteria:
1. Septic shock diagnosis \> 48 hours before
2. Receive intravenous fluid \< 30 mL/kg before enrollment
3. Do-not-resuscitation and terminally ill
4. Refractory to treatment malignancy
5. Pregnancy
7\. Chronic renal failure stage 5 with no plan for long term renal replacement therapy 8. Cirrhosis child C 9. Cardiogenic shock 10. Acute decompensated heart failure 11. Evidence of left ventricular ejection fraction (LVEF) \< 35% 12. Acute coronary syndrome within 72 hours 13. Severe valvular heart disease 14. Documented life-threatening tachyarrhythmia before enrollment 15. Diagnosis of acute mesenteric ischemia before enrollment 16. Previous diagnosis of Raynaud's phenomenon 17. Known peripheral arterial disease 18. Refuse to sign the informed consent by patient or representative
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT04339868
Study Brief:
Protocol Section:
NCT04339868