Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 12:36 PM
Ignite Modification Date:
2025-12-24 @ 12:36 PM
NCT ID:
NCT04660461
Eligibility Criteria:
Inclusion Criteria:
1. Patients ≥18 years old
2. Patients diagnosed with PXE according to 2010 criteria by PLOMP et al.
3. At least, patients meet two of the following criteria:
1. Retinal lesions such as Orange peel and/or Angioid streaks
2. Skin lesions such as papules or yellowish plaques on the lateral face of the neck and / or flexures of the body (armpits, elbows, knees) or alterations in the skin biopsy with fragmentation and / or conglomerates of and / or calcification of the elastic fibers.
3. A pathogenic mutation of the two alleles of the ABCC6 gene.
Exclusion Criteria:
1. Refusal of informed consent.
2. Vegetarian diet or extreme diets.
3. Pregnancy or its intention during the months of the study.
4. Age \<18 years old
5. Known hypersensitivity to "prazoles" or proton pump inhibitors.
6. Intake of medications that may interfere with Lansoprazole and that cannot be withdrawn or modified in its form of administration to avoid such interference.
7. Prior taking of proton pump inhibitors, except for a wash out period of 15 days if the clinical situation of the patient allows it.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT04660461
Study Brief:
Protocol Section:
NCT04660461