Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:59 PM
Ignite Modification Date:
2025-12-24 @ 4:59 PM
NCT ID:
NCT00006150
Eligibility Criteria:
* INCLUSION CRITERIA:
Patients may be included in this study who:
* Were referred to the NIH with a diagnosis or a suspicion of Hyper IgE syndrome.
* Are patients referred for other immune syndromes that demonstrate some of the characteristics of HIES.
* Are male or female, aged
Aged
* \>=1 month for affected subjects
* Aged \>=2 years for unaffected subjects
* For unaffected subjects, are able to understand and have the willingness to sign a written informed consent document.
Unaffected biological relatives of HIES patients are also eligible to enroll in a separate relative cohort.
EXCLUSION CRITERIA:
Coronary CTA will not be performed on any patient younger than 30 years or with contraindication to IV contrast media. This includes patients with 1) creatinine value of \>1.3 mg/dL, 2) history of multiple myeloma, 3) Use of metformin-containing products less than 24 hours prior to contrast media, and 4) history of significant allergic reaction to CT contrast agents despite the use of premedication.
Subjects with a medical, psychiatric, or social condition which, in the opinion of the investigator, would place undue burden on the subject, NIH resources, or increase risk of participation, may be excluded.
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
1 Month
Maximum Age:
120 Years
Study:
NCT00006150
Study Brief:
Protocol Section:
NCT00006150