Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:52 PM
Ignite Modification Date:
2025-12-24 @ 4:52 PM
NCT ID:
NCT04414150
Eligibility Criteria:
Inclusion Criteria:
1. Voluntary participation and written informed consent;
2. Aged 18-75 years (inclusive), males and females;
3. Patient must have histologically or clinically confirmed advanced and/or metastatic malignancies for which failure of standard treatment or lack of effective standard treatment;
4. At least one measurable lesion according to RECIST v1.1;
5. ECOG score of 0-1;
6. Expected survival ≥ 12 weeks;
7. Adequate bone marrow reserve and organ function were confirmed by baseline examination
8. For female patients of childbearing potential or male patients with partners of childbearing potential who are not sterilized by surgical operations, they are required to use a medically approved contraceptive measure during the study treatment period and within 3 months after the end of the study treatment; For female patients of childbearing potential who are not sterilized by surgical operations, they must have a negative serum HCG test result within 72 h prior to study enrollment; and they must not be in the lactation period;
Exclusion Criteria:
1. The presence of any active, known, or suspected autoimmune disease. Type 1 diabetes, which was admitted to receive stable dose of insulin, hypothyroidism, which required only hormone replacement therapy, skin disease with no need to systemic treatment and no acute exacerbation within 1 year before the screening period;
2. Subjects who had received systemic treatment with corticosteroids or other immunosuppressive agents within 28 days prior to initial administration.
3. Known and untreated central nervous system (CNS) or leptomeningeal metastases;
4. Uncontrolled pleural effusion,or ascites requiring recurrent drainage procedures;
5. Uncontrolled cardiac diseases or symptoms;
6. Known hereditary or acquired bleeding and thrombotic tendencies;
7. Patients who have previously received chemotherapy, radiotherapy or surgery which ended within 4 weeks prior to the start of this study; oral molecular targeted therapy with \< 5 drug half-lives from the first study dose; or patients with AEs caused by previous treatment (except for alopecia) that have not returned to CTCAE Grade ≤ 1;
8. Known active infection,;
9. Congenital and acquired immune deficiency;
10. HBsAg-positive and HBV DNA \> 2000 IU/mL(or 104 copies/mL); HCV RNA copies \> ULN;
11. Patients with other potential factors that may affect the study results or result in the premature discontinuation as determined by the investigator, such as alcoholism, drug abuse, other serious diseases (including mental illness) requiring concomitant treatment, serious laboratory abnormalities, or family or social factors that could affect the safety of the patients.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
75 Years
Study:
NCT04414150
Study Brief:
Protocol Section:
NCT04414150