Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:51 PM
Ignite Modification Date:
2025-12-24 @ 4:51 PM
NCT ID:
NCT00024050
Eligibility Criteria:
DISEASE CHARACTERISTICS:
* Diagnosis of low or intermediate-risk myelodysplastic syndrome
* Refractory anemia (RA)
* RA with ringed sideroblasts
* No advanced myelodysplastic syndrome (i.e., at least 5% blasts in the marrow, more than 1% blasts in the peripheral blood, or blasts in the cerebrospinal fluid)
* No poor-risk cytogenetics (i.e., abnormalities of chromosome 7 or complex abnormalities)
* HLA-A, B, C, DRB1, and DQB1 compatible related or unrelated donor available
* Mismatch for a single HLA-A, B, C, DRB1, or DQB1 allele allowed
PATIENT CHARACTERISTICS:
Age:
* 65 and under
Performance status:
* Not specified
Life expectancy:
* Not specified
Hematopoietic:
* Not specified
Hepatic:
* AST no greater than 2 times normal
Renal:
* Creatinine no greater than 2 times upper limit of normal
* Creatinine clearance at least 50%
Cardiovascular:
* No cardiac insufficiency requiring treatment
* No symptomatic coronary artery disease
Pulmonary:
* No severe hypoxemia (pO2 less than 70 mm Hg with DLCO less than 70% predicted)
* No mild hypoxemia (pO2 less than 80 mm Hg with DLCO less than 60% predicted)
Other:
* No other disease that would limit life expectancy
* HIV negative
* Not pregnant or nursing
PRIOR CONCURRENT THERAPY:
Biologic therapy
* Not specified
Chemotherapy
* Not specified
Endocrine therapy
* Not specified
Radiotherapy
* Not specified
Surgery
* Not specified
Healthy Volunteers:
False
Sex:
ALL
Maximum Age:
65 Years
Study:
NCT00024050
Study Brief:
Protocol Section:
NCT00024050