Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:46 PM
Ignite Modification Date:
2025-12-24 @ 4:46 PM
NCT ID:
NCT00073450
Eligibility Criteria:
Inclusion Criteria:
* Histologically or cytologically proven squamous cell carcinoma of the head \& neck.
* Age greater than or equal to 18.
* ECOG performance status of 0 to 1
* Measurable malignant disease.
* Patients that have failed at least one platinum-containing regimen and have received no more than three prior regimens and do not have other curative treatment options.
* Patients must be at least 2 wks post surgery or radiation therapy
* Patients must be at least 4 weeks post chemotherapy
* Meets protocol requirements for specified laboratory values.
* Written informed consent and cooperation of patient.
* Appropriate use of effective contraception if of childbearing potential.
* No investigational drugs of any type within 30 days prior to administration.
Exclusion Criteria:
* Prior exposure to farnesyl transferase inhibitors
* Medical conditions that would interfere with taking oral medications.
* Patients with significant QTc prolongation at baseline (\>500 msec.)
* Pregnant or nursing women
* Known HIV positivity or AIDS-related illness.
* Concomitant chemotherapy, hormonal therapy, radiotherapy or immunotherapy
* Patients with any signs of involvement of the dura, meninges, or brain.
* Patients with squamous cell carcinoma of the nasopharynx
* Patients who currently have other cancers or have been treated in the last 5 years for any other malignancy.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00073450
Study Brief:
Protocol Section:
NCT00073450