Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:46 PM
Ignite Modification Date:
2025-12-24 @ 4:46 PM
NCT ID:
NCT03658850
Eligibility Criteria:
Inclusion Criteria:
* hospitalized for intensive care,
* Over 18 years of age,
* Two serum sodium measurements above 145 mEq / L (with no pre-determined interval between them),
* Mean arterial pressure greater than 65mmHg
Exclusion Criteria:
* Absence of consent to participate in the study
* Cardiac index below 2.5L / min / m2 OR signs of ineffective circulation (capillary filling time greater than 2 seconds, cold or sticky skin) OR arterial lactate\> 4mMol / L.
* Use of vasopressors at doses greater than 0.1 mcg / kg / min of noradrenaline or with initiation or increase of dose within less than one hour before inclusion in the study.
* Unavailable enteral route.
* Use of hydrochlorothiazide in the last 7 days of ICU admission.
* History of allergy or intolerance to hydrochlorothiazide or other thiazides.
* Nephrogenic Diabetes Insipidus.
* Renal impairment KDIGO 3
* Indication of renal replacement therapy.
* Acute neurological insult.
* Heart failure American Heart Association classification (AHA), class D.
* Liver cirrhosis Child-Pugh C.
* Pregnant women
* Exclusive palliative care
* Dying, with expected survival less than 48 hours
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT03658850
Study Brief:
Protocol Section:
NCT03658850