Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:44 PM
Ignite Modification Date:
2025-12-24 @ 4:44 PM
NCT ID:
NCT01488266
Eligibility Criteria:
Inclusion Criteria:
* Patients who are older than 20 years of age have a diagnosis of MDD without psychotic features, as defined by DSM-IV-TR.
* Patients have to report an inadequate response to a current antidepressant treatment. Inadequate response to antidepressant is defined as: total score of HDRS-17 is more than 14), despite adequate dose of current antidepressant treatment for at least 6 weeks in the current episode(co-administered with ATRQ)
* Classification of antidepressants which can be included in the study(list for suggestion): Escitalopram 10\~20mg/day, fluoxetine 20\~40mg/day,paroxetine controlled release(CR) 25\~62.5mg or paroxetine 20\~40mg, sertraline 100\~150mg,bupropion XL(SR) 150\~300mg, mirtazapine 15\~45mg,venlafaxine immediate or extended release(IR or ER) 112.5\~225mg/day, duloxetine 60mg \[same criteria for generic medications as brand drugs\]
Exclusion Criteria:
* Those who are first episode, drug naive MDD subjects
* Those who have a current Axis I diagnosis of delirium, dementia, amnestic or other cognitive disorder, schizophrenia or other psychotic disorder, bipolar 1 or 2 disorder, eating disorder, obsessive-compulsive disorder, panic disorder, or posttraumatic stress disorder
* Those who have a clinically significant current Axis 2 diagnosis of borderline, antisocial, paranoid, schizoid, schizotypal, or histrionic personality disorder
* Those who experience hallucinations, delusion, or any psychotic symptomatology in the current depressive episode
* Those who have met DSM-IV-TR criteria for any significant substance use disorder within the past 12 months (except nicotine)
* Those who have known allergy,hypersensitivity or previous unresponsiveness to aripiprazole or known intolerance to other study medications
* Those who have had cognitive-behavioral therapy or other psychotherapy, or they have the potential need to be treated with them during the study periods
* Those who are complicated with serious medical problem, such as severe renal, hepatic dysfunction, cardiovascular, lung, gastrointestinal, endocrine, nervous, infectious disease, or neoblastic, metabolic disease
* Those who have shown previous unresponsiveness to adequate antidepressant trials more than 2 episodes or with 3 or more antidepressant treatments
* Those who have chronic liver or renal disease
* Those who are pregnant or brest-feeding
* Those who have participated in a clinical trial with aripiprazole or any other investigational product within the past month(include randomized, double-blind, placebo-controlled or open-label study; but chart review,observational study can be enrolled)
* Those who had a history of thyroid pathology, neuroleptic malignant syndrome, or serotonin syndrome
* Those who have received adjunctive antipsychotic plus antidepressant for more than 3 weeks during the current episode
* Those who have received electroconvulsive therapy for the current episode
* Those who have shown an inadequate response to previous ECT in any episode
* Those who have a suicidal risk
* Those who are likely to require prohibited concomitant therapy during the trial
* Those who have received treatment with a monoamine oxidase inhibitor within 2 weeks prior to enrollment
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
20 Years
Study:
NCT01488266
Study Brief:
Protocol Section:
NCT01488266