Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:37 PM
Ignite Modification Date:
2025-12-24 @ 4:37 PM
NCT ID:
NCT01902966
Eligibility Criteria:
Inclusion Criteria:
1. Proven recurrent cervical cancer of any histology not eligible for curative radiotherapy or surgery.
2. Failed chemotherapy for first recurrence (excluding chemotherapy with concurrent irradiation) or refractory to first line systemic therapy.
3. Measurable or non-measurable disease
4. Unlimited prior therapies
Exclusion Criteria:
1. Patients whose disease may be cured by surgery or radiotherapy.
2. Contraindication to use of a beta-blocker.(uncontrolled DM, COPD-unstable, Bradycardia \<50 BPM)
3. Already receiving a beta-blocker.
4. Performance status \>3. Must have had treatment for first line recurrence
5. Prior radiation therapy for localized cancer of the breast, head and neck, or skin is permitted provided that it was completed more than 3 years prior to registration, and the patient remains free of recurrent or metastatic disease.
6. With the exception of non-melanoma skin cancer and other specific malignancies as noted above, patients with other invasive malignancies who had (or have) any evidence of the other cancer present within the last five years or whose previous cancer treatment contraindicates this protocol therapy are excluded.
7. Use of systemic glucocorticoids such as Prednisone or Decadron in the last month for greater than one week
8. Inability to accurately answer questions (e.g. dementia, brain metastases) or speak English or Spanish.
9. Cirrhosis of the liver
10. Patients under the age of 18
11. History of comorbid conditions: Addison's disease, autoimmune hepatitis, hepatitis B, hepatitis C, AIDS or HIV, lupus erythematosus, mixed connective tissue disease, rheumatoid arthritis.
12. Hypersensitivity to propranolol, or beta-blockers
13. Uncompensated congestive heart failure
14. Cardiogenic shock
15. Severe sinus bradycardia; heart block, second or third degree or sick sinus syndrome (if no artificial pacemaker present)
16. Severe hyperactive airway disease (chronic obstructive pulmonary disease, asthma)
17. Any patients on Avastin or any other anti-angiogenic drugs.
18. Patients with brittle diabetes mellitus (DM). Brittle diabetes mellitus is a type of diabetes when a person's blood glucose (sugar) level often swings quickly from high to low and from low to high. Also called "unstable diabetes" or "labile diabetes."
19. Patients participating in or who plan to participate in other treatment trials during the course of this study.
20. Patients actively using cocaine
21. Cannot be receiving any other active neoplastic treatment during 4 months of study.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT01902966
Study Brief:
Protocol Section:
NCT01902966