Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:28 PM
Ignite Modification Date:
2025-12-24 @ 4:28 PM
NCT ID:
NCT07178366
Eligibility Criteria:
Inclusion Criteria:
* ACLF patients of any etiology with systemic inflammatory response syndrome and AARC grade II or more.
Exclusion Criteria:
* Patients eligible for corticosteroids for severe alcohol-associated hepatitis related ACLF (other than hydrocortisone according to Surviving Sepsis Campaign Guidelines 2021 which is 50 mg iv q 6 h for management of refractory shock
* Hepatocellular carcinoma or any extrahepatic malignancy,
* Active fungal sepsis
* Disseminated intravascular coagulation
* Hemodynamic instability requiring norepinephrine \>0.20ug/kg/min
* Patients with coma of non-hepatic origin
* Patients with PaO2/FiO2 ratio \<150
* Pregnancy
* Comorbidities associated with poor outcomes (severe cardiopulmonary disease defined by a New York Heart Association score \>3, or oxygen/steroid-dependent chronic obstructive pulmonary disease, chronic kidney disease) and patients with post-resection liver failure
* Patients with fibrinogen \<110 and/or platelets less than 50,000
* Patients with oliguria with urine output less than 400 ml/day
* Lack of informed consent
* Patient enrolled in other clinical trials
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT07178366
Study Brief:
Protocol Section:
NCT07178366