Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:27 PM
Ignite Modification Date:
2025-12-24 @ 4:27 PM
NCT ID:
NCT05974566
Eligibility Criteria:
Inclusion Criteria:
* Age ≥ 18 years
* New York Heart Association(NYHA) functional classification II - IV
* LVEF measured by the echocardiogram ≤ 45%
* eGFR\>25mL/min/1.73m²
Exclusion Criteria:
* LVEF measured by the echocardiogram \> 45%
* History of allergic or hypersensitivity to drugs involved in the trial.
* Patients with a known history of cancer, angioedema, significant congenital heart disease or rheumatic heart disease.
* Patients diagnosed with myocarditis.
* Probable alternative diagnoses could account for the patient's HF symptoms e.g., COPD, bronchial asthma, primary pulmonary hypertension.
* Systolic blood pressure (SBP) ≥180mmHg or diastolic blood pressure (DBP)
* 120mmHg at visit, DBP≤90mmHg or symptomatic hypotension.
* Patients with cardiac pacemaker
* Pregnant woman
* eGFR≤25mL/min/1.73m² and not accept long-term hemodialysis therapy.
* Serum potassium \>5.2 mmol/l at visit
* Fatal or uncontrollable heart arrythmia e.g., symptomatic or persistence ventricular tachycardia, ventricular rate\>150 bpm in AF patients.
* Obvious stenosis (≥50%) of bilateral renal arteries.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT05974566
Study Brief:
Protocol Section:
NCT05974566