Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:20 PM
Ignite Modification Date:
2025-12-24 @ 4:20 PM
NCT ID:
NCT02116166
Eligibility Criteria:
Inclusion Criteria:
* males and females aged 20-35.
* willing and able to give informed consent.
Exclusion Criteria:
* High physical activity level (i.e., the subject has spent greater than 300 minutes per week in the past 2 month performing structured physical activity, such as exercising at a gym and/or weight training)
* Active treatment for cancer or history of cancer in the past 3 years
* Congestive heart failure NYHA Class III or IV
* Previous stroke with upper and/or lower extremities involvement within the last 6 months
* Peripheral vascular disease Fontaine Class III/IV
* History of life-threatening cardiac arrhythmias, stroke, severe Parkinson's disease or severe neurological disorders likely to interfere with physical function
* Renal disease requiring dialysis
* Lung disease requiring steroids
* Lower extremity amputation
* Complicated diabetes
* Life-threatening illnesses with an estimated life expectancy less than 1 year
* Anticoagulant therapy (aspirin use is allowed, but participants will be asked to stop taking it 48 hours prior to muscle biopsy)
* Involved in active weight loss \> 5 kg in prior 3 months
* Pregnancy (determined by a pregnancy test)
* Lidocaine allergy
Temporary exclusion criteria:
* Recent bacterial infection (\< 2 weeks)
* Acute febrile illness in previous 2 months
* High blood pressure (i.e., BP ≥ 160/90 mm Hg) at the visit (subject will be referred to his/her physician and reevaluated after appropriated therapy being instituted)
* Taking aspirin within 48 hours preceding biopsy
* Performing exercise 48 hours prior to the biopsy.
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
20 Years
Maximum Age:
35 Years
Study:
NCT02116166
Study Brief:
Protocol Section:
NCT02116166