Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 3:59 PM
Ignite Modification Date:
2025-12-24 @ 3:59 PM
NCT ID:
NCT00937092
Eligibility Criteria:
Inclusion Criteria:
* patients with New York Heart Association (NYHA) functional class IV heart failure according to the American Heart Association (AHA) classification, namely dyspnea on minimal exertion or rest dyspnea, orthopnea, and paroxysmal nocturnal dyspnea
* signs of congestion (third heart sound or pulmonary rales on physical examination)
* pulmonary congestion on chest x-ray
* serum B-type natriuretic peptide levels \> 400 pg/ml or NT-proBNP \> 1500 pg/ml
* echocardiographic documentation of systolic or diastolic dysfunction
* all candidate patients must be:
* Age \>18 years old
* on medical therapy with an ACE-inhibitor and/or a β-blocker
* experiencing an acute decompensation of known chronic HF
* Having baseline oxygen saturation \<90% on admission arterial blood gas
Exclusion Criteria:
* the investigators will exclude patients with:
* acute de novo HF
* severe renal failure (serum creatinine \> 200 μmol/L or GFR \< 30 ml/min/1.73m2)
* admission systolic blood pressure \< 90 mm Hg
* severe valvular disease
* known adverse reactions to furosemide or dopamine
* HF secondary to congenital heart disease
* a scheduled procedure with a need for IV contrast dye
* a scheduled cardiac surgery within 6 months
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
90 Years
Study:
NCT00937092
Study Brief:
Protocol Section:
NCT00937092