Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 12:16 PM
Ignite Modification Date:
2025-12-24 @ 12:16 PM
NCT ID:
NCT05539261
Eligibility Criteria:
Inclusion Criteria:
* Aged 45-80 years old.
* Accept heart biological valve replacement or heart valvuloplasty.
* More than 6 years of Education.
* At baseline, the score of Mini-mental State Examination (MMSE) scale is more than 23 points
Exclusion Criteria:
* Patients who failed to obtain informed consent.
* Preoperative diagnosis of stroke, epilepsy, history of craniocerebral surgery, cerebrovascular disease, psychosis and rescue patients with cardiopulmonary resuscitation before operation.
* Alcoholism, illiteracy and left-handed.
* There was severe organ hypoperfusion or organ dysfunction before operation, including: preoperative myocardial infarction \< 90 days, renal failure or dialysis, severe liver injury, digestive tract ischemia, spinal cord ischemia and iliac artery occlusion.
* There are contraindications to magnetic resonance examination, such as claustrophobia and metal implants in the body.
* Pregnant or lactating women.
* Participating in other clinical studies will affect the main indicators of this study.
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
45 Years
Maximum Age:
80 Years
Study:
NCT05539261
Study Brief:
Protocol Section:
NCT05539261