Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 3:52 PM
Ignite Modification Date:
2025-12-24 @ 3:52 PM
NCT ID:
NCT00183092
Eligibility Criteria:
Inclusion Criteria:
* Diagnosis of probable or definite sCJD: Definite--biopsy confirmed sCJD; Probable--a progressive dementia with either a typical EEG or a typical MRI consistent with sCJD, and at least two of the following clinical features: myoclonus, pyramidal or extrapyramidal signs, visual symptoms, cerebellar signs, akinetic mutism, other focal higher cortical neurologic signs (e.g. neglect, apraxia, aphasia)
* 18 years of age or older
* Able to swallow
* Able to follow simple one-step commands
* Have had a brain MRI within 6 months and an EEG within 3 months ruling out other etiologies such as masses, strokes, or non-convulsive status epilepticus
* Consent to autopsy in the event of their death during or after the study
Exclusion Criteria:
* History of other significant or life-threatening disease, including: cancer; end-stage liver or renal disease; severe heart disease
* History of other disease requiring regular supportive care
* Liver disease
* Active alcoholism
* Bone marrow suppression
* Severe hypotension
* Severe psoriasis
* Poorly controlled diabetes
* Women who are pregnant or breast-feeding
* Men, or women of childbearing age, not practicing reliable contraception
* Serious allergies to quinacrine or other acridines
* Current or recent use of quinacrine (within 6 months)
* \< 18 years of age
* Any other contraindication to taking quinacrine
* Genetic form of prion disease is identified prior to study enrollment
* Current use of anti-arrhythmics (at discretion of investigator)
* G6PD (Glucose 6-Phosphate Dehydrogenase) deficiency (at discretion of investigator)
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00183092
Study Brief:
Protocol Section:
NCT00183092