Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 3:51 PM
Ignite Modification Date:
2025-12-24 @ 3:51 PM
NCT ID:
NCT02614092
Eligibility Criteria:
Inclusion Criteria:
* Veterans aged 50 - 90
* diagnosis of aMCI
* available informant
* at least one musculoskeletal problem
* sufficient visual and auditory acuity to allow neuropsychological testing
* willingness to participate in exercise training +cognitive training program for eight months
* approval of primary provider to participate in an exercise trial
Exclusion Criteria:
* current untreated severe psychiatric disorder, such as:
* Bipolar I
* Schizophrenia
* or Major Depressive Disorder, determined by the Mini International Neuropsychiatric Interview (MINI)
* diagnosis of dementia, Clinical Dementia Rating (CDR) \> 0.5; modified Hachinski score 4; or delirium
* history of neurological disorder, e.g.:
* multiple sclerosis
* seizure disorder
* stroke
* history of transient ischemic attacks, or systemic illness affecting central nervous system (CNS) function, e.g.:
* liver failure
* kidney failure
* congestive heart failure
* systemic cancer
* acute illness or unstable chronic illness e.g., history of severe liver disease
* cirrhosis
* esophageal
* varices
* ascites
* portal hypertension
* hepatic encephalopathy
* current severe cardiac disease, e.g.:
* uncontrolled atrial fibrillation, defined as mean 24 hour heart rate \>85 beats/min, or 24 hour maximal ventricular rate \>150 beats/min
* uncontrolled ventricular arrhythmias, defined as recurrent ventricular tachycardia \> 3 beats in succession, or 24 hour packed cell volume (PVC) count \> 20%; active
* pericarditis or myocarditis
* Class III/IV heart failure and / or ejection fraction \< 20%
* thrombophlebitis
* pulmonary disease with a drop in O2 Sat with exercise to 90% without oxygen
* embolism within past six months
* inability to participate in an exercise stress test or inability to exercise consistently because of orthopedic or musculoskeletal problems
* morbid obesity (BMI \> 39)
* inability to read, verbalize understanding and voluntarily sign the Informed Consent
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
50 Years
Maximum Age:
90 Years
Study:
NCT02614092
Study Brief:
Protocol Section:
NCT02614092