Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 12:15 PM
Ignite Modification Date:
2025-12-24 @ 12:15 PM
NCT ID:
NCT00436761
Eligibility Criteria:
DISEASE CHARACTERISTICS:
* Diagnosis of malignant solid tumor
* Relapsed or refractory disease
* No isolated local recurrence of disease (in the site of the primary tumor) \> 1 year after completing therapy
* No brain tumors or brain metastases
* Unrelated cord blood donor available
* May be HLA 6/6 matched (HLA-A, -B, -DR) OR mismatched for 1, 2, or 3 of these HLA loci, but must be mismatched for HLA-C group as indicated by their following killer cell immunoglobulin-like receptor (KIR) group specificity:
* KIR2DL1
* Cw 2
* Cw 0307
* Cw 4, 5, 6
* Cw 0707, 0709
* Cw 1204, 1205
* All other Cw 15 alleles
* Cw 1602
* Cw 17
* Cw 18
* KIR2DL2
* Cw 1
* All other Cw 3 alleles
* All other Cw 7 alleles
* Cw 8
* Cw 1202, 1203, 1206
* Cw 1301
* Cw 1402, 1403
* Cw 1507
* Cw 1601, 1604
* Cord blood specimen must have ≥ 1 x 10\^7 nucleated cells/kg patient ideal body weight
PATIENT CHARACTERISTICS:
* ECOG performance status (PS) 0-2 OR Lansky PS 70-100%
* Cardiac ejection fraction ≥ 50%
* Creatinine clearance ≥ 50%
* Bilirubin ≤ 3.0 mg/dL
* DLCO ≥ 70% OR O\_2 saturation ≥ 95% on room air
PRIOR CONCURRENT THERAPY:
* Prior autologous stem cell transplantation allowed
Healthy Volunteers:
False
Sex:
ALL
Maximum Age:
21 Years
Study:
NCT00436761
Study Brief:
Protocol Section:
NCT00436761