Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 3:48 PM
Ignite Modification Date:
2025-12-24 @ 3:48 PM
NCT ID:
NCT04099992
Eligibility Criteria:
Inclusion Criteria:
* stages III and IV CKD as defined by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation
* stable renal function (no greater than a decline of eGFR of 1 cc/min/1.73 m2 per month over the prior 3 months)
Exclusion Criteria:
* severe CKD (eGFR\<15 cc/min)
* diabetic neuropathy
* autonomic dysfunction
* any serious disease that might influence survival
* anemia with hemoglobin \<10 g/dL
* treatment with central α-agonists or monoamine oxidase (MAO) inhibitors
* myocardial infarction or cerebrovascular accident within the past 6 months
* uncontrolled hypertension (BP≥170/100 mm Hg)
* low BP (BP\<100/50 mm Hg)
* bradycardia (HR\<55 beats/min)
* ongoing drug or alcohol abuse (defined as \>2 drinks/day in men, and \>1 drink/day in women)
* surgery within the past 3 months
* adjustment of antihypertensive medications within the past month
* pregnancy or plans to become pregnant
* psychosis
* suicidal ideation
* implanted electronic or metallic device such as a pacemaker
* implanted hearing aid, bone plate, carotid stent, bone screw at or near the neck
* carotid atherosclerosis
* concurrent use of another stimulating device such as a transcutaneous electrical nerve stimulation (TENS) unit
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
40 Years
Maximum Age:
80 Years
Study:
NCT04099992
Study Brief:
Protocol Section:
NCT04099992