Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 3:31 PM
Ignite Modification Date:
2025-12-24 @ 3:31 PM
NCT ID:
NCT01364792
Eligibility Criteria:
Inclusion Criteria:
* Age above 18
* Written informed consent for participation
* Diagnosis: schizophrenia, all subtypes (DSM-IV 295.xx)
* Psychosis, characterised by a total score on the positive scale on the PANSS above 14. In addition, a minimal score of 4 or more on an item of the positive scale.
Exclusion Criteria:
* The use of benzodiazepines. Benzodiazepines have affinity for the peripheral benzodiazepine receptor which is the target receptor for \[11C\]-PK11195 PET and they can thus interfere with the PET study.
* The use of a nonsteroidal antiinflammatory drug or paracetamol in week before the PET scans and during the treatment of valaciclovir
* The use of anticoagulants or having coagulation disorder
* Use of somatic medication which may affect the immune system (e.g. corticoids, anti-inflammatory drugs, immune suppressive drugs)
* Use of any investigational drug
* Current or recent (\<1 year) alcohol or substance abuse
* Disturbed kidney function
* Disturbed liver function
* Current or recent (\<4 weeks) infectious or inflammatory disease
* Current systemic disease
* Major metabolic disease (diabetes, hyper- or hypothyroidism, Cushing disease or Addison disease)
* Somatic, organic or neurological disorder
* Participation in a scientific research study (\<1 year) involving radiation
* Claustrophobia
* Presence of materials in the body that can be magnetized, like:
* A pacemaker
* Metal fragments
* Shunts
* Artificial heart valves
* Vascular clips
* Fixed hearing aid
* Tattoos containing metal
* Hair implants
* Artificial dentures
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT01364792
Study Brief:
Protocol Section:
NCT01364792