Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:21 PM
Ignite Modification Date:
2026-03-26 @ 3:21 PM
NCT ID:
NCT05806827
Eligibility Criteria:
The recruitment's inclusion criteria will select patients:
* Aged ≥ 65 years
* Undergoing elective surgical procedures, scheduled to last longer than one hour.
* Under general anaesthesia, including the procedures using mechanical ventilation, total intravenous anaesthesia (TIVA) or balanced anaesthesia.
* Planned inpatient length of stay in the hospital ≥ 2 days
* With and without preoperative exposure to the following neurotoxic viruses: SARS-CoV-2 (COVID-19), Herpes simplex virus (HS), Cytomegalovirus (CMV), and Epstein Barr virus (EBV).
Exclusion Criteria:
* Patients aged less than 65 years old.
* Undergoing non elective surgical procedures.
* Undergoing surgical procedures lasting less than one hour.
* Undergoing surgical procedures entailing the impairment of the verbal production, such as brain surgery, maxillofacial surgery and otorhinolaryngology operations. The surgical procedures excluded are the ones affecting the speech and cognitive functions and the surgeries with specific risks of postoperative cognitive impairment (such as cardiac surgery and carotid surgery).
* Undergoing surgical procedures implying local anaesthesia.
* Undergoing surgical procedures that do not imply the insertion of an airway device (such as endotracheal tube or laryngeal mask) or the protracted mechanical ventilation.
* Undergoing surgery procedures with planned mechanical ventilation after surgery / re-intubation.
* Patients with language barriers.
* Patients under legal guardianship and with pre-existing cognitive dysfunction (MoCA \< 21 points).
* Patients not giving the informed consent.
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
65 Years
Study:
NCT05806827
Study Brief:
Protocol Section:
NCT05806827