Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:21 PM
Ignite Modification Date:
2026-03-26 @ 3:21 PM
NCT ID:
NCT01555827
Eligibility Criteria:
Inclusion Criteria:
* Inclusion criteria for AD cases:
* Diagnosis of probable AD, defined according to the NINCDS-ARDRA criteria51
* Light to moderate severity of the disease, defined by a MMSE score \>10 (global evaluation of cognition)
* Patient aged 50 years or more
* Patient benefiting from social insurance
Inclusion criteria for controls:
* Absence of suspicion of dementia, based on normal performance according to age and educational level at neuropsychological testing defined as:
* Free recall ≥17 and total recall ≥40 for the Free and Cued Selective Reminding Test (Grober and Buschke test 52) MMSE ≥ norm for age and educational level (defined by mean - 1 SD)
* Isaac's set test ≥ norm for age and educational level (defined by mean - 1 SD)
* Matched to age and gender of the cases
* Patient benefiting from social insurance
Exclusion Criteria:
Exclusion criteria for all patients :
* History of Parkinson's disease or other neurodegenerative disorder
* History of Horton's disease
* History of inflammatory neuropathies (in particular Devic's disease, multiple sclerosis)
* History of vascular ischemic neuropathies and chronic intracranial hypertension
* History of pituitary tumors
* Presence of diseases (systemic and/or ocular diseases) or behavioural or cognitive symptoms incompatible with eye examination
* Known diabetes
* Person under tutorship or curatorship, person unable to express consent
Additional exclusion criteria for AD cases:
* Dementia of other cause than AD
* Severe AD, defined by MMSE score ≤ 10
Additional exclusion criteria for controls:
* Presence of dementia, of whatever cause
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
50 Years
Study:
NCT01555827
Study Brief:
Protocol Section:
NCT01555827