Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:20 PM
Ignite Modification Date:
2026-03-26 @ 3:20 PM
NCT ID:
NCT07346118
Eligibility Criteria:
Inclusion Criteria:
* Adults (≥ 18 years of age)
* Admitted to ICU
* Acute kidney injury by KDIGO criteria
* Initiated CRRT by at least one of the following indications for RRT initiation:
* Serum potassium ≥ 6.0 mmol/L, or
* pH ≤ 7.20 or serum bicarbonate ≤ 12 mmol/L, or
* Evidence of severe respiratory failure, based on a PaO2/FiO2 ≤ 200 and clinical perception of volume overload, or
* Persistent severe AKI (sCr remains \> 50% the value recorded at randomization) for \> 72 hours from randomization
* Participants giving informed consent
Exclusion Criteria:
* Refuse to participate
* Previous diagnosis of end-stage kidney disease (ESKD) currently on kidney replacement therapy
* Kidney transplant recipient
* Receive RRT before ICU admission within 90 days
* Structural kidney diseases which will interfere with intrarenal doppler ultrasound e.g. renal artery stenosis, autosomal dominant polycystic kidney disease
* Patients with previously known conditions that interfere with portal doppler assessment, namely liver cirrhosis, severe tricuspid regurgitation with structural heart disease or massive ascites.
* Underlying disease process with a life expectancy less than 90 days
* Pregnancy
* Severe cardiac rhythm disturbances (tachyarrhythmia, supraventricular tachycardia)
* Intra-cardiac shunts; Ventricle septal defect, patent foramen ovale, atrial septal defect
* Aortic aneurysm
* Intra-abdominal hypertension (intraabdominal pressure ≥20 mmHg)
* Expected life expectancy \<48 hours
* Receiving extracorporeal membrane oxygenation (ECMO)
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT07346118
Study Brief:
Protocol Section:
NCT07346118