Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:20 PM
Ignite Modification Date:
2026-03-26 @ 3:20 PM
NCT ID:
NCT07357220
Eligibility Criteria:
Inclusion Criteria:
1. Signed informed consent
2. Age≥18 years and ≤ 75 years
3. Histologically or cytologically confirmed unresectable colorectal cancer with liver metastases; adenocarcinoma type
4. Disease progression after first- or second-line standard therapy
5. At least one measurable disease based on RECIST v1.1
6. ECOG status of 0 or 1
7. Estimated life expectancy≥3 months
8. Adequate organ function
9. Patients with fertility are willing to use an adequate method of contraception
Exclusion Criteria:
1. Histologically or cytologically confirmed non-adenocarcinoma or mixed-type tumors with adenocarcinoma component ≤70%
2. Known dMMR or MSI-H
3. Known RAS or BRAF mutations
4. Participation in another clinical trial
5. Systemic anticancer therapy within 4 weeks, small molecule therapy within 2 weeks, antitumor traditional Chinese medicine within 2 weeks before first dose
6. Prior immunotherapy other than anti-PD-(L)1 agents
7. Live attenuated vaccine within 28 days before or during study treatment and 90 days after last dose
8. Active malignancy within the past 3 years
9. Known spinal cord compression, active brain or leptomeningeal metastases.
10. Significant bleeding events requiring transfusion, invasive intervention, or hospitalization within 3 months before first dose
11. Serious infection within 28 days, or systemic anti-infective therapy within 14 days before first dose (except antiviral therapy for hepatitis B/C)
12. Active herpesvirus infection with clinical manifestations
13. Active autoimmune disease
14. Known immunodeficiency
15. Known allergy to study drug or excipients, or history of severe allergic reactions to other vaccines
16. History of allogeneic organ or hematopoietic stem cell transplantation.
17. Clinically significant liver disease
18. Any other situations that are not suitable for inclusion in this study judged by investigator
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
75 Years
Study:
NCT07357220
Study Brief:
Protocol Section:
NCT07357220