Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:19 PM
Ignite Modification Date:
2026-03-26 @ 3:19 PM
NCT ID:
NCT07313605
Eligibility Criteria:
Inclusion Criteria:
1. Age 18 years or older
2. Within 24 hours of diagnosis of septic shock based on Sepsis-3 criteria (requirement for vasopressors to maintain organ perfusion, lactate greater than 2 mmol/L, suspected or confirmed infection)
3. Within 72 hours of ICU admission
4. Tachycardia with heart rate 100 beats per minute or greater, defined as either sinus tachycardia or atrial fibrillation/flutter
Exclusion Criteria:
1. Known allergy to beta-blockers
2. Second or third-degree heart block without a functioning pacemaker
3. Acute bronchospasm or status asthmaticus
4. Pregnancy
5. Patient receiving extracorporeal membrane oxygenation
6. Decision to limit life-sustaining therapies
7. Untreated pheochromocytoma
8. Fluid-responsive patients as determined by POCUS assessment
9. Moderate to severe right ventricular and/or systolic left ventricular dysfunction as determined by POCUS assessment
10. Patient already receiving calcium channel blocker or beta-blocker therapy
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT07313605
Study Brief:
Protocol Section:
NCT07313605