Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:19 PM
Ignite Modification Date:
2026-03-26 @ 3:19 PM
NCT ID:
NCT07366060
Eligibility Criteria:
Inclusion Criteria:
* Age 18 years or older
* Diagnosis of cervicogenic headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3)
* Availability of cranial and cervical spine imaging
* At least 5 headache days per month
* Inadequate response to pharmacological and/or physical therapy treatments
* Ability to understand and provide written informed consent
* Positive response to ultrasound-guided diagnostic third occipital nerve block, defined as at least 50% reduction in pain intensity or patient-reported meaningful improvement
Exclusion Criteria:
* Secondary headache disorders other than cervicogenic headache according to ICHD-3
* Signs or symptoms of cervical nerve root irritation and/or spinal stenosis
* Sensory deficit in the greater occipital nerve dermatome
* Cranio-cervical structural defects or anatomical abnormalities at or near the target site
* Local or systemic infection
* Non-pharmacological headache treatment within the last 3 months (e.g., physical therapy, botulinum toxin A, acupuncture, ozone therapy, cognitive behavioral therapy)
* Pregnancy or suspected pregnancy
* Known allergy to local anesthetic agents
* History of malignancy
* Known organic disease of the brain or spinal cord
* History of cranial or cervical surgery within the last 12 months
* Bleeding or coagulation disorders or use of oral anticoagulant therapy
* Comorbid conditions that may cause headache (e.g., uncontrolled hypertension, intracranial lesions)
* Conditions that may interfere with treatment adherence or outcome assessment (e.g., psychiatric disorders, dementia)
* Request for re-treatment due to development of contralateral pain or other pain conditions during follow-up
* Refusal to undergo the intervention or withdrawal of consent at any stage of the study
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT07366060
Study Brief:
Protocol Section:
NCT07366060