Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:18 PM
Ignite Modification Date:
2026-03-26 @ 3:18 PM
NCT ID:
NCT07448493
Eligibility Criteria:
Inclusion Criteria:
* Male and female patients aged 18 years or older;
* Histologically confirmed epithelial malignancy of the stomach (gastric adenocarcinoma), esophagus (esophageal adenocarcinoma), or gastroesophageal junction (GEJ adenocarcinoma). Patients with squamous cell carcinoma of the esophagus are also eligible;
* Radiologically ± histologically confirmed brain metastases, including:
* Solid brain parenchymal metastases
* Leptomeningeal disease (LMD)
* Both solid metastases and LMD
Exclusion Criteria:
* Synchronous or metachronous multiple primary malignancies (MPM) involving sites other than the stomach, esophagus, or gastroesophageal junction;
* Primary tumor located outside the stomach, esophagus, or gastroesophageal junction;
* Histologically confirmed non-epithelial gastrointestinal malignancy (e.g., neuroendocrine tumors, sarcoma, gastrointestinal stromal tumor, lymphoma);
* Isolated spinal cord involvement without brain parenchymal metastases;
* Incomplete medical records precluding assessment of at least one primary endpoint (OS, TTIP, or CNS-PFS). Patients with available data for any primary endpoint are eligible, even if other clinical details are missing.
* Prior local treatment for brain metastases at an outside institution with no available records, precluding determination of the first local treatment modality
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT07448493
Study Brief:
Protocol Section:
NCT07448493