Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:18 PM
Ignite Modification Date:
2026-03-26 @ 3:18 PM
NCT ID:
NCT07456358
Eligibility Criteria:
Inclusion Criteria:
* Adult patient (aged ≥ 18 years)
* Affiliated with a social security scheme
* Express consent to participate in the study
* Indication for lumbar puncture And
* Patients with cancer, undergoing treatment with ICIs, presenting neurological symptoms after starting treatment with ICIs. These symptoms must have appeared no more than 3 months after the last administration of ICIs.
Or
* Patients with an autoimmune disease of the central nervous system (diagnosis made by teams 1, 2 and 3) according to internationally recognised criteria, with no history of active cancer in the last 3 years and no other autoimmune disease Or
* Patients with normal pressure hydrocephalus (NPH) or idiopathic intracranial hypertension (diagnosed based on imaging (brain MRI) and clinical findings), with no history of active cancer in the last 3 years and no active autoimmune disease
Exclusion Criteria:
* Contraindication or refusal to perform a lumbar puncture
* Sample not suitable for research (volume of CSF collected for treatment \>5 mL)
* Corticosteroid therapy or other immunomodulatory treatment in progress (discontinued less than 15 days prior to inclusion)
* Pregnant or breastfeeding women
* Not affiliated with the social security system, patients under French State Medical Aid for undocumented migrants
* Patients under guardianship or curatorship, under judicial protection measures, or deprived of their liberty by judicial or administrative decision
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT07456358
Study Brief:
Protocol Section:
NCT07456358