Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:17 PM
Ignite Modification Date:
2026-03-26 @ 3:17 PM
NCT ID:
NCT07485569
Eligibility Criteria:
Inclusion Criteria:
* Patients with locally advanced or metastatic TC (such as ATC, PDTC, and RAI refractory DTC progressive under treatment with multikinase inhibitors) for whom no approved conventional treatments are available.
* Prior anticancer treatment-related toxicities resolved to Grade ≤1 (CTCAE v5.0).
* Measurable disease per RECIST 1.1
* ECOG performance status ≤ 2
* Negative pregnancy test within 7 days prior to starting the study in women of childbearing potential and adequate use of contraception.
Exclusion Criteria:
* Inability to provide informed consent
* Inability to obtain a (new) biopsy for molecular profiling
* Pregnancy or breastfeeding.
* Other active malignancies requiring therapy.
* Neutropenia (ANC \< 1.5 × 10⁹/L).
* Severe uncontrolled medical conditions (renal, cardiac, liver, respiratory).
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT07485569
Study Brief:
Protocol Section:
NCT07485569