Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:17 PM
Ignite Modification Date:
2026-03-26 @ 3:17 PM
NCT ID:
NCT07343232
Eligibility Criteria:
Inclusion Criteria:
1. Age \> 18 years.
2. Confirmed diagnosis of aneurysmal subarachnoid hemorrhage (aSAH), with the presence of an aneurysm verified by computed tomography (CT), CT angiography (CTA), or digital subtraction angiography (DSA).
3. Hunt-Hess grade II-IV.
4. Presence of hypocapnia on arterial blood gas analysis, defined as PaCO2 \< 35 mmH;
5. PaO2 \> 90 mmHg.
Exclusion Criteria:
1. Presence of brain herniation or refractory intracranial hypertension, defined as a baseline intracranial pressure (ICP) \> 25 mmHg that responds poorly to conventional ICP-lowering therapy;
2. Primary respiratory diseases (e.g., chronic obstructive pulmonary disease, severe asthma) known to cause chronically elevated baseline PaCO2;
3. Severe acid-base disturbances other than respiratory alkalosis.
4. Severe cardiac insufficiency, severe hepatic or renal dysfunction, malignant tumors, or other severe comorbidities that significantly impact prognosis;
5. Before the onset of the disease, the mRS score was greater than 2, and there were other factors causing disability.
6. Life expectancy \< 3 months;
7. Any other condition deemed by the investigator to pose a high risk warranting exclusion.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT07343232
Study Brief:
Protocol Section:
NCT07343232