Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:15 PM
Ignite Modification Date:
2026-03-26 @ 3:15 PM
NCT ID:
NCT07437768
Eligibility Criteria:
Inclusion Criteria:
* Patients aged between 20 and 75 years.
* Outpatients at Fu Jen Catholic University Hospital who had undergone esophagogastroduodenoscopy (EGD) within the past year.
* Presence of persistent GERD symptoms, including acid regurgitation, heartburn, chest pain, globus sensation, or chronic cough. PPI-refractory GERD, defined as persistent symptoms despite receiving at least 8 weeks of standard-dose proton pump inhibitor (PPI) therapy (GerdQ \> = 8).
* Scheduled to undergo high-resolution manometry (HRM) and 24-hour esophageal pH-impedance monitoring.
* Patients with a history of any grade of erosive esophagitis confirmed by gastroscopy.
Exclusion Criteria:
* major esophageal motility disorders
* history of upper gastrointestinal surgery
* malignant tumors
* liver cirrhosis.
* esophageal strictures
* esophageal varices
* gastrointestinal obstruction
* significant acute GI bleeding
* LA Grade B, C, or D erosive esophagitis,
* esophageal peptic stricture
* biopsy-proven Barrett's esophagus
* severe renal impairment (CrCl \< 30 mL/min)
* long-term dialysis, pregnancy
* hypersensitivity to vonoprazan or its excipients.
* patients currently taking atazanavir sulfate or rilpivirine hydrochloride,
* dependent on tube feeding
* unable to cooperate due to impaired consciousness
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
20 Years
Maximum Age:
75 Years
Study:
NCT07437768
Study Brief:
Protocol Section:
NCT07437768