Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:15 PM
Ignite Modification Date:
2026-03-26 @ 3:15 PM
NCT ID:
NCT07465666
Eligibility Criteria:
Inclusion criteria:
1. Adult male or female patients (≥18 years).
2. Patients with physician-diagnosed hypertension (as defined by the American Heart Association/American College of Cardiology international guidelines).
3. Patients who are either antihypertensive therapy naïve or currently receiving antihypertensive monotherapy (ACE inhibitor/ARB/CCB) with a physician-directed requirement to transition to ARNi.
Note: Patients who transition from one monotherapy to another during the study are not eligible for inclusion.
4. Patients willing to provide written informed consent to participate in the study.
Exclusion criteria:
1. Patients with malignant or severe hypertension (systolic blood pressure \[SBP\] ≥180 mmHg, diastolic blood pressure \[DBP\] ≥110 mmHg) at baseline.
2. Patients with secondary causes of hypertension, as determined by the treating physician.
3. Patients with a history of, or at risk of developing, angioedema.
4. Patients with evidence of severe renal impairment (e.g., estimated glomerular filtration rate \[eGFR\] \<30 mL/min/1.73 m\^2).
5. Pregnant or lactating women.
6. Patients with serum potassium level ≥5.5 mmol/L at baseline.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
99 Years
Study:
NCT07465666
Study Brief:
Protocol Section:
NCT07465666