Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2026-03-26 @ 3:14 PM
Ignite Modification Date:
2026-03-26 @ 3:14 PM
NCT ID:
NCT07304661
Eligibility Criteria:
Inclusion Criteria:
1. Adult patients aged ≥18 years
2. Patients admitted to the intensive care unit receiving mechanical ventilation
3. Presence of suspected intravascular fluid deficit (hypotension, negative fluid balance, or clinical signs of peripheral hypoperfusion)
4. Patients in sinus rhythm
5. Presence of invasive arterial blood pressure monitoring
6. Adequate echocardiographic window allowing transthoracic echocardiographic measurement of LVOT VTI
7. Patients ventilated with tidal volume ≥8 mL/kg (ideal body weight)
8. Hemodynamically stable enough to allow measurement
Exclusion Criteria:
1. Patients under 18 years of age
2. Presence of atrial fibrillation or significant arrhythmias such as frequent ventricular or atrial ectopy
3. Severe right ventricular dysfunction or significant tricuspid regurgitation
4. Advanced aortic valve disease (severe stenosis or severe regurgitation)
5. Patients with significant spontaneous breathing effort
6. Patients receiving lung-protective low tidal volume ventilation strategy (\<8 mL/kg) due to ARDS
7. Inadequate echocardiographic window for LVOT VTI assessment
8. Severe hemodynamic instability during measurement (sudden vasopressor escalation or need for resuscitation)
9. Patients who refuse to participate or from whom written informed consent cannot be obtained from themselves or a first-degree relative
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT07304661
Study Brief:
Protocol Section:
NCT07304661