Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 3:22 PM
Ignite Modification Date:
2025-12-24 @ 3:22 PM
NCT ID:
NCT05242692
Eligibility Criteria:
Inclusion Criteria:
* Aged 60 years or over
* Both genders
* American anesthesiologist association (ASA) physical status classificationⅠ-Ⅲ
* Diagnosed with lung, esophagus, or mediastinum disorders
* Undergoing open or video-assisted thoracic surgery including lobectomy, segmentectomy, pneumonectomy, esophagectomy, or resection of mediastinal tumor
* General anesthesia with one-lung ventilation (OLV) or bronchial blocker.
* An expected operation duration of 2 hours or more.
* Voluntarily participate in the trial and sign informed consent.
Exclusion Criteria:
* History of psychiatric disease or severe depression
* History of glaucoma or hyperthyroidism
* History of severe hepatic (Child-Pugh grade C) or renal (requirement for renal replacement therapy) disorder.
* Body mass index (BMI) greater 35 kg/m2
* Dementia history or baseline Mini-Mental State Examination (MMSE) score less than 23
* Severe audio-visual impairments, or inability to speak Mandarin or Cantonese precluding communication
* Sinus bradycardia (heart rate \< 50 beats per minutes, bpm), sick sinus or Wolff- Parkinson-White syndromes, or Ⅱ degree atrioventricular block and over
* Poorly controlled hypertension (resting systolic blood pressure over 180 mm Hg, or resting diastolic blood pressure over 100 mm Hg)
* Allergic to dexmedetomidine, S-ketamine or any of their formulation ingredients;
* Taking sedatives, antidepressants or glucocorticoids
* Alcohol or drug abuser
* Life expectancy of less than 2 months due to extensive tumor metastasis.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
60 Years
Maximum Age:
90 Years
Study:
NCT05242692
Study Brief:
Protocol Section:
NCT05242692