Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 3:04 PM
Ignite Modification Date:
2025-12-24 @ 3:04 PM
NCT ID:
NCT00404859
Eligibility Criteria:
Inclusion Criteria:
* Asthma is defined as a chronic inflammatory disorder, leading to recurrent episodes of wheezing, breathlessness, chest tightness, and/or coughing, based on variable airway obstruction \[18\]. Children with docter-diagnosed asthma known at the department of Paediatric Pulmonology, were recruited from the University Hospital Maastricht. Atopic and not atopic asthmatic children were allowed; treatment with inhalation corticosteroïd (ICS) was not obliged.
* Children known with CF were recruited from University Hospital Maastricht. CF was defined as a combination of typical clinical features and an abnormal sweat test (Chloride \> 60 mM). CF lung disease was treated according to the CBO consensus ref. Main aspects of treatment were:
* antibiotic treatment,
* agents to promote airway secretion clearance, such as DNase,
* bronchodilators, and,
* physiotherapy. All alternations of medical therapy were allowed and accurately documented.
Exclusion Criteria:
* Diseases that may interfere with the results of the study (e.g. upper airway infection, cor vitium, anatomic abnormalities of the airway and other chronic inflammatory diseases, such as Morbus Crohn and rheumatoid arthritis),
* Mental retardation,
* Inability to perform measurements properly,
* Active smoking and,
* Use of the following medication: papaverin, sodium nitroprusside, angiotensin-converting enzyme (ACE) inhibitors, oxymetazoline, L-arginine, or nitric oxide synthase (NOS) inhibitors
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
5 Years
Maximum Age:
46 Years
Study:
NCT00404859
Study Brief:
Protocol Section:
NCT00404859