Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 2:53 PM
Ignite Modification Date:
2025-12-24 @ 2:53 PM
NCT ID:
NCT00296959
Eligibility Criteria:
Inclusion Criteria:
* UK PD Society Brain Bank criteria for the diagnosis of idiopathic PD.
* Patients with stable levodopa-induced dyskinesias present greater than 25% of the day (Unified Parkinson's Disease Rating Scale (UPDRS), item 32, rating \> 2) and be moderately to completely disabling (UPDRS item 33, rating \> 2).
* All anti-parkinsonian medications must be stable for at least one month prior to study enrollment.
Exclusion Criteria:
* Include prior surgery for PD
* Hoehn and Yahr score of 5 when "off"
* History of nephrolithiasis
* Renal impairment
* Liver disease
* Pregnancy
* Premenopausal females and males not using adequate contraception
* Cognitive impairment (Mini Mental State Exam score less than 24)
* History of glaucoma or seizures
* Use of other antiepileptic drugs
* Amantadine
* Carbonic anhydrase inhibitors
* Digoxin
* Metformin
* Or illicit drugs
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
30 Years
Maximum Age:
75 Years
Study:
NCT00296959
Study Brief:
Protocol Section:
NCT00296959