Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 5:03 AM
Ignite Modification Date:
2025-12-25 @ 5:03 AM
NCT ID:
NCT00491218
Eligibility Criteria:
Inclusion Criteria:
1. Chest pain or anginal equivalent symptoms possibly suggestive of symptomatic coronary artery disease.
2. Low-intermediate risk (\<75% pretest probability) for symptomatic coronary artery disease on basis of age, sex, and quality of reported symptom as classified by the Diamond and Forrester scheme6
3. Referred to Walter Reed Cardiology clinic for an exercise treadmill test as the initial diagnostic test of choice
4. Age equal to or greater than 18 years and less than 70 years
5. Ability to provide informed consent
Exclusion Criteria:
1. Abnormal baseline electrographic changes that would preclude proper diagnosis of ischemia including preexcitation (Wolff-Parkinson-White) syndrome, a paced ventricular rhythm, more than 1 mm of ST depression at rest, complete left bundle branch block, or criteria for left ventricular hypertrophy, even if they have less than 1 mm of baseline ST depression
2. Presence of known pre-existing coronary artery disease (known prior myocardial infarction, EKG evidence of prior infarction, prior angiographic evidence of significant coronary artery disease, history of prior coronary revascularization).
3. Previous outpatient or inpatient evaluation for coronary artery disease to include exercise treadmill testing, stress echocardiography or nuclear myocardial perfusion studies within the last three years.
4. Presence of signs or symptoms that are clearly compatible with non-cardiac chest pain, including musculoskeletal, gastrointestinal or neuropathic causes.
5. Renal insufficiency (creatinine \>1.5mg/dl) or renal failure requiring dialysis.
6. Baseline heart rate \> 100bpm, atrial fibrillation or other markedly irregular rhythm (frequent ectopy, multifocal atrial tachycardia) on baseline ECG.
7. Pregnancy or unknown pregnancy status.
8. Known allergy to iodinated contrast.
9. Inability to tolerate beta-blocking drugs, including patients with reactive airways disease requiring maintenance inhaled bronchodilators or steroids, complete heart block or second-degree atrioventricular block.
10. Patients with hyperthyroidism including Grave's disease and toxic multinodular goiter
11. Computed tomography imaging, or iodinated contrast administration over 50 ml, within the past 48 hours.
12. Unwillingness to withhold ingestion of metformin or commonly used erectile dysfunction medications (Viagra, Cialis, Levitra) for 48 hours prior to MSCT scan.
13. Previous history of radiation therapy to the thorax.
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
70 Years
Study:
NCT00491218
Study Brief:
Protocol Section:
NCT00491218