Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 2:53 PM
Ignite Modification Date:
2025-12-24 @ 2:53 PM
NCT ID:
NCT01186159
Eligibility Criteria:
Inclusion Criteria:
* The trial is approved by Tongji hospital's Ethics Committee, Tongji Medical College of Huazhong University of Science and Technology, and is registered through Clinical Trail. All patients give written informed consent
* American Society of Anesthesiologists (ASA) physical status of I or II
* 20 years to 55 years
* Weight 50 \~ 70 kg, BMI 19 \~ 24
* Duration of operation time in the range of 2-4 hours
* A normal leukocytes level before the operation
* No alcohol or smoking abuse
* Without major trauma, history of psychiatric disease and history of chronic pain
* Patients agreement with the trial and having ability to complete the requirements of this study
* Patients receiving intravenous patient controlled analgesia (PCA)
Exclusion Criteria:
* Allergy or contraindication to selective COX-2 inhibitors
* Received NSAIDs treatments before the operation
* Used enzyme inhibitor (such as Ketoconazole, Fluconazole, Itraconazole), enzyme inducer (such as Rifampicin, Phenytoin sodium, Carbamazepine, Dexamethasone), anticoagulant (such as Warfarin, Aspirin) and other drugs which increase the drug toxicity (such as Erythromycin, Clarithromycin, Cyclosporin Ciclosporin, ACE inhibitor or Diuretics, Lithium) from the first 3 days before the operation to postoperative observation period
* Blood transfusion, hemodilution measures in the operation
* Infection of the incision
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
20 Years
Maximum Age:
55 Years
Study:
NCT01186159
Study Brief:
Protocol Section:
NCT01186159